Comparative Biochemistry and Physiology Part C: Comparative Pharmacology
Mini-reviewThe allometric approach for interspecies scaling of pharmacokinetic parameters
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A minimal physiologically based pharmacokinetic model that predicts anti-PEG IgG-mediated clearance of PEGylated drugs in human and mouse
2018, Journal of Controlled ReleaseApplication of a health risk assessment model for cattle exposed to pesticides in contaminated drinking waters: A study case from the Pampas region, Argentina
2018, ChemosphereCitation Excerpt :Although the rat NOAEL was used as a surrogate toxicity endpoint in an equine risk assessment carried out by Schleier III et al. (2008), we otherwise preferred to extrapolate the missing cattle toxicological data from rodents and dogs, as done by Riviere et al. (1997), applying the allometric method because of the following advantages. This method is based on the premise that many physiologic parameters are a function of the size (body weight) of the animal species (Ritschel et al., 1992). The use of a fractional power of body weight to derive toxicologically equivalent doses across species is an accepted practice supported by literature (Sharma and McNeill, 2009; Wang and Prueksaritanont, 2010; USEPA, 2011; Moyer et al., 2014).
Xenograft models for preclinical drug testing: Implications for adrenocortical cancer
2012, Molecular and Cellular EndocrinologyCitation Excerpt :Animal data are scaled-up to predict pharmacokinetics and pharmacodynamics in men using this empirical allometric method. However, this approach can be generally used for compounds metabolized and excreted by the kidney (Ritschel et al., 1992). For compounds metabolized in the liver and excreted in the bile other models may allow a better prediction, taking into account physiological properties of the species and biochemical characteristics of the drugs (Poulin and Theil, 2002).
Interspecies scaling in pharmacokinetics: A novel whole-body physiologically based modeling framework to discover drug biodistribution mechanisms in vivo
2012, Journal of Pharmaceutical SciencesCitation Excerpt :In particular, West's group developed a model to explain the origin of quarter-power scaling laws and their use in determining metabolic rates when organism body sizes vary over large orders of magnitude.20,21 Another concept, interspecies scaling with invariant PK time, results in the removal of the differences in concentration–time profiles due to chronological time.22 Unfortunately, interspecies extrapolation with these simple scaling laws is not satisfactory because it does not account for fundamental biochemical mechanisms, but merely incorporates weight or size factors.
Light, Water, and Melatonin: The Synergistic Regulation of Phase Separation in Dementia
2023, International Journal of Molecular Sciences