The Journal of Steroid Biochemistry and Molecular Biology
Anabolic steroids: A review of their effects on the muscles, of their possible mechanisms of action and of their use in athletics
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Developments and challenges in human performance enhancement technology
2021, Medicine in Novel Technology and DevicesNandrolone alter left ventricular contractility and promotes remodelling involving calcium-handling proteins and renin-angiotensin system in male SHR
2018, Life SciencesCitation Excerpt :Cardiac remodelling usually contributes to the loss of heart contractile capacity, increasing the rigidity or reducing the complacency of the ventricular wall, which can result in heart failure [23,24]. Regarding the NDL effects observed in our study, it is important to take into account the presence of androgenic receptors in the myocardium [25,26]. The binding of androgens to these receptors initiate gene transcription processes and, consequently, protein translation, therefore modulating androgen-dependent cellular actions [25,27,28].
Spectroscopic and molecular docking techniques study of the interaction between oxymetholone and human serum albumin
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2013, Journal of Chromatography ACitation Excerpt :Due to the ability to improve the physical performance in human sports [1–3] anabolic androgenic steroids (AAS) are one of the groups of prohibited substances according to the World Anti-Doping Agency (WADA) [4].
Preconcentration and spectrophotometric determination of oxymetholone in the presence of its main metabolite (mestanolone) using modified maghemite nanoparticles in urine sample
2013, TalantaCitation Excerpt :Anabolic-androgenic steroids (AAS) represent an important class of abused drugs in sport, and are classified as prohibited substances according to World Anti-Doping Agency [2]. The main desired effects of these testosterone-derived compounds are their potential ability to improve physical performance of skeletal muscle and to balance catabolic condition in body after stress [3,4]. In addition, mediated mainly by their androgenic activity, the AAS have the potency also to cause serious health problems as side effects, e.g. cardiovascular or liver diseases [3].