The Journal of Steroid Biochemistry and Molecular Biology
Rapid communicationThe hydrolysis of oestrone sulphate and dehydroepiandrosterone sulphate by human steroid sulphatase expressed in transfected COS-1 cells
References (21)
Steroid sulfation: current concepts
Trends Endocr. Metab.
(1993)Purification and partial characterization of aryl sulphatase C from human placental microsomes
Biochim. Biophys. Acta
(1983)- et al.
Cloning and expression of steroid sulphatase cDNA and frequent occurrence of deletions in STS deficiency: implications for X-Y interchange
Cell
(1987) - et al.
Cloning and expression of human steroid sulphatase
J. Biol. Chem.
(1989) - et al.
Characterization of rat and human steroid sulphates
Biochim. Biophys. Acta
(1989) - et al.
The characterization of oestrone sulphate from human plasma
J. Biol. Chem.
(1961) - et al.
Binding of the sulphates of oestradiol-17β to human serum albumin and plasma
J. Clin. Endocr. Metab.
(1975) - et al.
Effect of plasma estrogen sulphates in mammary cancer cells
Endocrinology
(1980) - et al.
Interaction of 5-androstene-3β,17β-diol with estradiol and dihydrotestosterone receptors in human myometrial and mammary tissue
J. Clin. Endocr. Metab.
(1985) - et al.
Stimulation of cell proliferation and estrogenic response by adrenal C19-delta5-steroids in the ZR-75-1 human breast cancer cell line
Cancer Res.
(1986)
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Conjugated estrogens in the endometrium during the estrous cycle in pigs
2018, Reproductive BiologyCitation Excerpt :The transport of sulphated estrogens across the membrane of tissue cells is carried out by various membrane transporters of the solute carrier family (SLC) and the ATP-binding cassette transporter family (ABC) [16–19]. The steroid sulphatase (STS) is, in turn, able to catalyze the hydrolysis of the sulphate moiety resulting in the formation of free estrogens [20]. This process of reversible estrogen sulphation and desulphation is proposed to be an endogenous regulatory mechanism that enables the availability of biologically active estrogen in target tissues [21].
Δ<sup>4</sup>-3-ketosteroids as a new class of substrates for the cytosolic sulfotransferases
2017, Biochimica et Biophysica Acta - General SubjectsCitation Excerpt :These latter enzymes play an important role in the metabolism of steroids in the body [11]. For example, DHEA sulfate (DHEAS), produced primarily under the action of SULT2A1, is the most abundant adrenal steroids in circulation, and when transported to peripheral tissues it may be converted to DHEA by steroid sulfatase (STS) [12–13]. DHEA serves as a principal precursor for the synthesis of downstream sex steroids such as 17β-estradiol and testosterone [14].
Estrogen O-sulfamates and their analogues: Clinical steroid sulfatase inhibitors with broad potential
2015, Journal of Steroid Biochemistry and Molecular BiologyCitation Excerpt :Also, androstenediol is formed from androstenediol sulfate, itself derived from dehydroepiandrosterone sulfate (DHEAS) and both of these are substrates for STS. STS was found to hydrolyze readily both DHEAS and estrone sulphate, thus indicating that only one sulfatase exists for both estrogen and androgen pathways [10]. Thus, inhibition of STS should not only affect the in situ generation of estrone and estradiol, as above, but also should block the other pathway of estrogenic stimulation via androstenediol, both pathways importantly being independent of aromatase inhibition.
Role of enzymes and tissue-specific actions of steroids
2004, MaturitasDevelopment of novel steroid sulfatase inhibitors: II. TZS-8478 potently inhibits the growth of breast tumors in postmenopausal breast cancer model rats
2004, Journal of Steroid Biochemistry and Molecular BiologySteroid sulphatase inhibitors for breast cancer therapy
2003, Journal of Steroid Biochemistry and Molecular Biology