Circulating antigen: Bad or good for immunoscintigraphy?
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Evaluation of <sup>111</sup>In labeled antibodies for SPECT imaging of mesothelin expressing tumors
2011, Nuclear Medicine and BiologyCitation Excerpt :Prior studies in human patients injected with radiolabeled antibodies against carcinoembryonic antigen (CEA) have shown that although there is formation of immune complexes with the circulating antigens, the localization of activity into the tumors remains unaffected and there is no marked clearance of the radiolabel in the liver or the spleen. As a result, tumor detection by γ-immunoscintigraphy remained unaffected [42]. Nonetheless, if spleen uptake of 111In-mAbMB is observed in human patients, pre-administration of unlabeled mAbMB may be used as a strategy to reduce the spleen uptake.
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