P-glycoprotein: Its role in drug resistance

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References (55)

  • DoigeCA et al.

    ATPase activity of partially purified P-glycoprotein from multidrug-resistant Chinese hamster ovary cells

    Biochim Biophys Acta

    (1992)
  • Al-ShawiMK et al.

    Characterization of the adenosine triphosphatase activity of Chinese hamster P-glycoprotein

    J Biol Chem

    (1993)
  • GarrigosM et al.

    Absence of co-operativity for MgATP and verapamil effects on the ATPase activity of P-glycoprotein containing membrane vesicles

    Biochem Biophys Res Commun

    (1993)
  • LooTW et al.

    Reconstitution of drug-stimulated ATPase activity following coexpression of each half of human P-glycoprotein as separate polypeptides

    J Biol Chem

    (1994)
  • ShapiroAB et al.

    ATPase activity of purified and reconstituted P-glycoprotein from Chinese hamster ovary cells

    J Biol Chem

    (1994)
  • KamimotoY et al.

    The function of Gpl70, the multidrug resistance gene product, in rat liver canalicular membrane vesicles

    J Biol Chem

    (1989)
  • DoigeCA et al.

    Transport properties of P-glycoprotein in plasma membrane vesicles from multidrug-resistant Chinese hamster ovary cells

    Biochim Biophys Acta

    (1992)
  • GuiralM et al.

    Co-operative P-glycoprotein mediated daunorubicin transport into DNA-loaded plasma membrane vesicles

    FEBS Lett

    (1994)
  • SharomFJ et al.

    Functional reconstitution of drug transport and ATPase activity in proteoliposomes containing partially purified P-glycoprotein

    J Biol Chem

    (1993)
  • EndicottJA et al.

    The biochemistry of P-glycoprotein-mediated multidrug resistance

    Ann Rev Biochem

    (1989)
  • GottesmanMM et al.

    Biochemistry of multidrug resistance mediated by the multidrug transporter

    Ann Rev in Biochem

    (1993)
  • ChildsS et al.

    The MDR superfamily of genes and its biological implications

  • MorrowCS et al.

    Glutathione-S-transferases and drug resistance

    Cancer Cells

    (1990)
  • ColeSPC et al.

    Identification of a novel ATP-binding cassette transporter gene over-expressed in a multidrug resistant human lung cancer cell line

    Science

    (1992)
  • BeckWT et al.

    Drug resistance associated with altered DNA topoisomerase II

    Adv Enzyme Regul

    (1993)
  • BellDR et al.

    Detection of P-glycoprotein in ovarian cancer: a molecular marker associated with multidrug resistance

    J Clin Oncol

    (1985)
  • GoldsteinLJ et al.

    Expression of a multidrug resistance gene in human tumors

    J Natl Canc Inst

    (1989)
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      In these tissues, the transporters are thought to play a role in protection against the cytotoxic effects of toxins and xenobiotics (multiple drug resistance) by limiting toxin/drug entry into certain tissues and promoting their elimination into the bile and urine (Fromm, 2000). The identification of cancer stem-like cells has further raised the interest in the SP technique, and the SP phenotype might explain the resistance of a subpopulation of tumor cells to chemotherapy (Chua et al., 2008; Dean et al., 2005; Hirschmann-Jax et al., 2004; Ling, 1995; Szotek et al., 2006; Wu et al., 2007). SP cells have been identified in a number of cancers where they have been shown to display increased capacity of self-renewal and tumorigenicity when transplanted into immunocompromised mice (Bleau et al., 2009; Chiba et al., 2006; Chua et al., 2008; Haraguchi et al., 2006; Ho et al., 2007; Mitsutake et al., 2007; Patrawala et al., 2005; Wu and Alman, 2008; Wu et al., 2007).

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