P-glycoprotein: Its role in drug resistance
References (55)
- et al.
Multidrug resistance and chemosensitization: therapeutic implications for cancer chemotherapy
Adv Pharmacol
(1990) - et al.
Homozygous disruption of the murine mdr 2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
Cell
(1993) - et al.
Phosphatidylcholine translocase: a physiological role for the mdr2 gene
Cell
(1994) - et al.
Disruption of the mouse mdrla P-glycoprotein gene leads to a deficiency in the blood brain barrier and to increased sensitivity to drugs
Cell
(1994) What determines the substrate specificity of the multidrug resistance pump?
Trends Brachem Sci
(1990)- et al.
Structure and function of P-glycoprotein in normal liver and small intestine
Adv Pharmacology
(1993) - et al.
Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins
Cell
(1986) - et al.
Internal duplications and homology with bacterial transport proteins in the mdr 1 (P-glycoprotein) gene from multidrug-resistant human cells
Cell
(1986) - et al.
Purification of the 170–180 kilodalton membrane glycoprotein associated with multidrug resistance
J Biol Chem
(1988) - et al.
P-glycoprotein: ATP hydrolysis by the N-terminal nucleotide binding domain
J Biol Chem
(1992)
ATPase activity of partially purified P-glycoprotein from multidrug-resistant Chinese hamster ovary cells
Biochim Biophys Acta
Characterization of the adenosine triphosphatase activity of Chinese hamster P-glycoprotein
J Biol Chem
Absence of co-operativity for MgATP and verapamil effects on the ATPase activity of P-glycoprotein containing membrane vesicles
Biochem Biophys Res Commun
Reconstitution of drug-stimulated ATPase activity following coexpression of each half of human P-glycoprotein as separate polypeptides
J Biol Chem
ATPase activity of purified and reconstituted P-glycoprotein from Chinese hamster ovary cells
J Biol Chem
The function of Gpl70, the multidrug resistance gene product, in rat liver canalicular membrane vesicles
J Biol Chem
Transport properties of P-glycoprotein in plasma membrane vesicles from multidrug-resistant Chinese hamster ovary cells
Biochim Biophys Acta
Co-operative P-glycoprotein mediated daunorubicin transport into DNA-loaded plasma membrane vesicles
FEBS Lett
Functional reconstitution of drug transport and ATPase activity in proteoliposomes containing partially purified P-glycoprotein
J Biol Chem
The biochemistry of P-glycoprotein-mediated multidrug resistance
Ann Rev Biochem
Biochemistry of multidrug resistance mediated by the multidrug transporter
Ann Rev in Biochem
The MDR superfamily of genes and its biological implications
Glutathione-S-transferases and drug resistance
Cancer Cells
Identification of a novel ATP-binding cassette transporter gene over-expressed in a multidrug resistant human lung cancer cell line
Science
Drug resistance associated with altered DNA topoisomerase II
Adv Enzyme Regul
Detection of P-glycoprotein in ovarian cancer: a molecular marker associated with multidrug resistance
J Clin Oncol
Expression of a multidrug resistance gene in human tumors
J Natl Canc Inst
Cited by (48)
Neurocognitive Function in Adult Cancer Patients
2018, Neurologic ClinicsCitation Excerpt :Carriers of the epsilon 4 (ε4) allele of apolipoprotein E (ApoE), a variant associated with impairments in neuronal membrane repair and synaptic plasticity,45 may portend a selective vulnerability to neurotoxicity from chemotherapy.46 Several additional genes have been postulated to play a role as well (Table 2).47–52 Imaging studies reveal structural and functional brain changes with chemotherapy.
Critical appraisal of the side population assay in stem cell and cancer stem cell research
2011, Cell Stem CellCitation Excerpt :In these tissues, the transporters are thought to play a role in protection against the cytotoxic effects of toxins and xenobiotics (multiple drug resistance) by limiting toxin/drug entry into certain tissues and promoting their elimination into the bile and urine (Fromm, 2000). The identification of cancer stem-like cells has further raised the interest in the SP technique, and the SP phenotype might explain the resistance of a subpopulation of tumor cells to chemotherapy (Chua et al., 2008; Dean et al., 2005; Hirschmann-Jax et al., 2004; Ling, 1995; Szotek et al., 2006; Wu et al., 2007). SP cells have been identified in a number of cancers where they have been shown to display increased capacity of self-renewal and tumorigenicity when transplanted into immunocompromised mice (Bleau et al., 2009; Chiba et al., 2006; Chua et al., 2008; Haraguchi et al., 2006; Ho et al., 2007; Mitsutake et al., 2007; Patrawala et al., 2005; Wu and Alman, 2008; Wu et al., 2007).
Abcb1a and Abcb1b expression in senescence-accelerated mouse (SAM)
2009, Neuroscience LettersStructure-activity relationships of new inhibitors of breast cancer resistance protein (ABCG2)
2008, Bioorganic and Medicinal ChemistryDistinct N-glycan glycosylation of P-glycoprotein isolated from the human uterine sarcoma cell line MES-SA/Dx5
2007, Biochimica et Biophysica Acta - General SubjectsRole of drug efflux transporters in the brain for drug disposition and treatment of brain diseases
2005, Progress in Neurobiology