Short communicationGenetic polymorphism of paraoxonase 1 (PON1) and susceptibility to Parkinson's disease
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Acknowledgements
This study was supported by a Grant-in-Aid for Scientific Research on Priority Areas (I.K.) from the Ministry of Education, Science and Sports of Japan.
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2023, Pathology Research and PracticeAnalysis of PON1 gene polymorphisms (rs662 and rs854560) and inflammatory markers in organophosphate pesticides exposed cohorts from two distinct populations.
2020, Environmental ResearchCitation Excerpt :PON1 is a serum esterase/lactonase which is synthesized by the liver and found exclusively on the high-density lipoproteins (HDL) surfaces. Expression and activity changes of PON1 have been shown to influence relative toxicity of OPs (Kahl et al., 2018; Kondo et Yamamoto, 1998; Lescai et al., 2009; Martínez-Salazar et al., 2011; Medina-Díaz et al., 2017). Several epidemiological studies (Araoud et al., 2010; Bernal-Hernández et al., 2014; Hofmann et al., 2009) have reported decreased PON 1 activity in OPs exposed workers.
Pig PON1: Expression and promoter methylation
2018, Gene ReportsHDL and cognition in neurodegenerative disorders
2014, Neurobiology of DiseaseCitation Excerpt :Supporting this notion, the activity of paraoxonase 1 (PON1), an apoA-I/HDL associated enzyme that exerts anti-oxidative and anti-inflammatory effects (Aviram and Rosenblat, 2004), has been shown to be decreased in PD (Ikeda et al., 2011). Several studies have also reported that individuals with polymorphisms in the PON1 gene associated with decreased enzyme activity have an increased risk of developing PD (Akhmedova et al., 2001; Kondo and Yamamoto, 1998; Zintzaras and Hadjigeorgiou, 2004). It is also noteworthy that similar to apoA-I, α-synuclein adopts a unique amphipathic helical structure that mediates reversible lipid binding (Bussell and Eliezer, 2003).
Novel common and rare genetic determinants of paraoxonase activity: FTO, SERPINA12, and ITGAL
2013, Journal of Lipid ResearchDietary cholesterol increases paraoxonase 1 enzyme activity
2012, Journal of Lipid ResearchCitation Excerpt :PON1 has broad substrate specificity, not only metabolizing pesticides but also statins (54) and the quorum-sensing factor of pseudomonas aeruginosa (55, 56). PON1 has an equally broad influence on human health, having been linked to vascular disease, Parkinson's disease (57–59), systemic lupus erythematosus (60–62), breast cancer (63, 64), age-related macular degeneration (65–71), and diabetes (36, 37) among other disorders. A fuller understanding of the determinants of PON1 activity should include the effects of diet.