Elsevier

Brain Research

Volume 806, Issue 2, 28 September 1998, Pages 271-273
Brain Research

Short communication
Genetic polymorphism of paraoxonase 1 (PON1) and susceptibility to Parkinson's disease

https://doi.org/10.1016/S0006-8993(98)00586-1Get rights and content

Abstract

Toxicologists have thought that the paraoxonase (PON) enzyme polymorphism might contribute to effects of pollutants and other environmental chemicals on susceptibility to cancer, birth defects and Parkinson's disease (PD). We studied a biallelic PON1 polymorphism at codon 192 (A and B alleles) in 166 patients with sporadic idiopathic PD. The frequency of the B (Arg) allele of PON1 was significantly increased in patients with PD than in healthy controls (χ2=8.75, df=1, P<0.005). The relative risk of PD in homozygotes for the B allele was 1.60 fold higher than individuals with the A (Gln) allele (χ2=7.38, df=1, P<0.01). Our data suggest that environmental neurotoxins metabolized by PON1 might be responsible for neurodegeneration with aging and that the B (Arg) allele form might have genetic susceptibility to PD.

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Acknowledgements

This study was supported by a Grant-in-Aid for Scientific Research on Priority Areas (I.K.) from the Ministry of Education, Science and Sports of Japan.

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