Pig hepatocytes as an in vitro model to study the regulation of human CYP3A4: prediction of drug-drug interactions with 17α-ethynylestradiol
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The utility of the minipig as an animal model in regulatory toxicology
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2008, Comparative Biochemistry and Physiology - C Toxicology and PharmacologyAcetaminophen-induced hepatotoxicity of gel entrapped rat hepatocytes in hollow fibers
2006, Chemico-Biological InteractionsCitation Excerpt :As these in vitro models frequently minimize the volume and cost of screening as well as the amount of compounds required, much of the early ADME/Tox evaluation relies on in vitro studies before the initiation of any in vivo animal testing. Monolayer cultures of hepatocytes have been widely used to investigate drug metabolism [2,3], drug–drug interactions [4,5] and mechanism of hepatotoxicities [6,7]. However, it has been generally recognized that primary hepatocytes in monolayer culture are subject to a gradual loss of liver-specific functions, with a special reference to decreased CYP isoforms [8].
Phase I and II metabolism and carbohydrate metabolism in cultured cryopreserved porcine hepatocytes
2005, Chemico-Biological InteractionsCitation Excerpt :Pascussi et al. [25] have found that low concentrations of dexamethasone (100 nM) induce expression of RXR and PXR and thereby CYP3A4 in human hepatocytes and this could theoretically upregulate 6β-hydroxylation of testosterone. 6β-hydroxylation in pig has been found to correlate with a CYP3A4 related protein according to Olsen et al. [20] and Monshouwer et al. [26]. In agreement with the hypothesis, Hengstler et al. [6] have shown that rat hepatocytes were almost equally inducible before and after cryopreservation.