Flavonoids: Old and new aspects of a class of natural therapeutic drugs

doi:10.1016/S0024-3205(99)00120-4

Life Sciences

Volume 65, Issue 4, 18 June 1999, Pages 337-353

https://doi.org/10.1016/S0024-3205(99)00120-4 Get rights and content

Abstract

Flavonoids are natural products widely distributed in the vegetable kingdom and currently consumed in large amounts in the daily diet. Flavonoids are capable of modulating the activity of enzymes and affect the behaviour of many cell systems, suggesting that the compounds may possess significant antihepatotoxic, antiallergic, anti-inflammatory, antiosteoporotic and even antitumor activities. This review summarizes available data on these beneficial effects of flavonoids.

References (102)

B. Havsteen
Biochem. Pharmacol.
(1983)
C.F. Timberlake et al.
Endeavour
(1986)
J. Kuhnau
World Rev. Nutr. Diet
(1976)
G. Samuelsson
T. Swain
C. Rice-Evans
A.M. Hackett
M.A. Djordjevic et al.
The Embo J.
(1987)
J.L. Firmin et al.
Nature
(1986)

N.K. Peters et al.

Science

(1986)

D.A. Smith et al.

S.A. Zaat et al.

J. Bacteriol.

(1987)

A. Beretz et al.

J. Eaton-Evans

Br. J. Biomed. Sci.

(1994)

H. Soike et al.

Planta Medica

(1987)

M.E. Bracke et al.

Plant Flavonoids in Biology and Medicine II. Progress in Clinical and Biological Research

(1988)

E.E. Deschner et al.

Carcinogenesis

(1991)

M.M. Iwu et al.

J.Pharm.Pharmacol

(1990)

D. Pathak et al.

Fitoterapia

(1991)

A.A. Izzo et al.

Phytother. Res.

(1994)

A. Capasso et al.

Phytother. Res.

(1991)

A. Capasso et al.

J. Ethnopharmacology

(1991)

G. Di Carlo et al.

J. Pharm. Pharmacol.

(1993)

R. Landolfi et al.

Biochem. Pharmacol.

(1984)

E. Middleton et al.

Biochem. Pharmacol.

(1992)

W. Król et al.

Biochem. Pharmacol.

(1995)

M. Gabor

C. Timeus

A. Beretz et al.

Planta Medica

(1991)

P. Morazzoni et al.

Fitoterapia

(1986)

E. Mian et al.

Minerva Medica

(1976)

A. Gottsegen

E. Magliulo et al.

Arzneim. Forsch.

(1973)

M.M. Iwu

Experientia

(1985)

R. Campos et al.

J.E. Robbers et al.

Pharmacognosy and Pharmacobiotechnology

R. Vijayaraghavan et al.

Toxicology

(1991)

N.S. Parmar et al.

Flavonoids and Bioflavonoids

T. Harada et al.

Jpn. J. Vet. Soc.

(1984)

R.J.F. Markham et al.

J. Gen. Microbiol.

(1987)

A.H. Gilani et al.

Biochem.Soc.Trans.

(1997)

P.A. Berg et al.

M. Amellal et al.

Planta Medica

(1985)

I. Yamazaki et al.

Life Sci.

(1986)

C.V. Albanese et al.

Biochem. Biophys. Res. Comm.

(1994)

M. Giossi et al.

Calcif. Tissue Int.

(1996)

M. Bracke et al.

Clin. Exp. Metastasis

(1991)

C. Kandaswami et al.

Cancer Lett.

(1991)

H.C. Huang et al.

Eur. J. Pharmacol.

(1994)

Cited by (1204)

1,8-Dihydroxy-3-methoxy-anthraquinone inhibits tumor angiogenesis through HIF-1α downregulation
2024, Biochemical Pharmacology
Photorhabdus luminescens is a gram-negative bioluminescent bacterium known as an intestinal bacterium that coexists in the digestive tract of insect-pathogenic nematodes. As part of our ongoing exploration to identify bioactive compounds from diverse natural resources, the chemical analysis of the cultures of P. luminescens KACC 12254 via LC/MS and TLC-based analyses enabled the isolation and identification of a major fluorescent compound. Its chemical structure was elucidated as 1,8-dihydroxy-3-methoxyanthraquinone (DMA) using HR-ESI-MS and NMR analysis. In this study, we conducted comprehensive investigations utilizing human colorectal cancer HCT116 cells, human umbilical cord vascular endothelial cells (HUVECs), and zebrafish embryos to assess the potential benefits of DMA in suppressing tumor angiogenesis. Our results convincingly demonstrate that DMA effectively suppresses the stability of hypoxia-inducible factor-1α (HIF-1α) protein and its target genes without inducing any cytotoxic effects. Furthermore, DMA demonstrates the ability to inhibit HIF-1α transcriptional activation and mitigate the production of reactive oxygen species (ROS). In our in vitro experiments, DMA exhibits notable inhibitory effects on VEGF-mediated tube formation, migration, and invasion in HUVECs. Additionally, in vivo investigations using zebrafish embryos confirm the antiangiogenic properties of DMA. Notably, DMA does not exhibit any adverse developmental or cardiotoxic effects in the in vivo setting. Moreover, we observe DMA's capability to restrain tumor growth through the downregulation of PI3K/AKT and c-RAF/ERK pathway. Collectively, these compelling findings underscore DMA's potential as a promising therapeutic candidate for targeted intervention against HIF-1α and angiogenesis in cancer treatment.
Quercetin supplementation in the diet of Labeo rohita: Effects on growth, proximate composition, antioxidative indices and immunity
2023, Animal Feed Science and Technology
This experiment was conducted to investigate the effects of quercetin supplementation on the growth performance, antioxidant indices, and immunity of Labeo rohita. Five experimental diets were formulated with quercetin inclusion rates of 0 g/kg (T_0, control), 2 g/kg (T₂), 4 g/kg (T₄), 6 g/kg (T₆), and 8 g/kg (T₈). Fish (N = 300) with an average initial weight of 12.8 ± 0.07 g were fed with one of the five diets for 90 days. At the end of experiment, the highest (p < 0.05) final weight (FW), absolute weight gain (AWG%), weight gain percentage (WG%) and specific growth rate (SGR) was observed in group fed the diet containing 4 g/kg quercetin. The best (p < 0.05) feed conversion ratio (FCR) was noted at 4 g/kg quercetin supplemented diet. Body indices such as viscerosomatic index (VSI) and hepatosomatic index (HSI) remained unaffected (p > 0.05). The muscle proximate composition was non-significantly (p > 0.05) affected by quercetin supplementation. The activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) tended to increase (p < 0.05) with increasing quercetin levels. However, an opposite trend (p < 0.05) was recorded in thiobarbituric acid reactive substance (TBARS). The immune parameters including lysozyme (LYZ), immunoglobulin (IgM) and alkaline phosphatase activity (AKP) were significantly enhanced (p < 0.05) up to 4 g/kg quercetin supplementation and decreased (p < 0.05) thereafter. The optimal dietary quercetin level for maximum WG% of L. rohita was determined as 4.11 g/kg through broken line regression analysis. In conclusion, quercetin supplementation up to 4.11 g/kg is recommended for better growth performance, antioxidant capacity, and immunity of L. rohita.
An in silico approach to unveil peptides from Acheta domesticus with potential bioactivity against hypertension, diabetes, cardiac and pulmonary fibrosis
2023, Food Research International
Entomophagy is a sustainable alternative source of proteins for human nutrition. Acheta domesticus is one of the three insect species that complies with the European Union Regulation on novel foods, but to date, there are no reports on their potential bioactive peptides. In this study, an in silico approach was applied to simulate the gastrointestinal (GI) digestion of six A. domesticus proteins and identify new peptides with potential anti-hypertensive and/or anti-diabetic properties, resulting from their capability to inhibit the somatic Angiotensin-I converting enzyme (sACE) and/or dipeptidyl peptidase 4 (DPP-4), respectively. A molecular docking protocol was applied to evaluate the binding interactions between the 43 peptides ranked with high probability of being bioactive and three drug targets: DPP-4 and two catalytic domains (N- and C-) of sACE. Five peptides (AVQPCF, CAIAW, IIIGW, DATW and QIVW) showed high docking scores for both enzymes, suggesting their potential to inhibit the DPP-4 and both catalytic domains of sACE, thus possessing multifunctional bioactive properties. Two peptides (PIVCF and DVW) showed higher docking scores for the N-domain of sACE, indicating a potential action as selective inhibitors and consequently with anti-cardiac and pulmonary fibrosis bioactivities. This is the first study identifying peptides originated from the simulated GI digestion of A. domesticus with potential activities against hypertension, diabetes, cardiac and pulmonary fibrosis.
The synthesis, crystal structure and spectroscopic analysis of (E)-3-(4-chlorophenyl)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)prop-2-en-1-one
2023, Acta Crystallographica Section E: Crystallographic Communications
Novel Substituted-dene-2-(-1,3-Diphenylallylidene) Hydrazine: Design, Synthesis, and in vitro Microbial Assessment
2024, Indian Journal of Pharmaceutical Education and Research
Dietary Polyphenols Effects on Focal Adhesion Plaques and Metalloproteinases in Cancer Invasiveness
2024, Biomedicines

View all citing articles on Scopus

View full text

MinireviewFlavonoids: Old and new aspects of a class of natural therapeutic drugs

Abstract

Biochem. Pharmacol.

Endeavour

World Rev. Nutr. Diet

The Embo J.

Nature

Science

J. Bacteriol.

Br. J. Biomed. Sci.

Planta Medica

Plant Flavonoids in Biology and Medicine II. Progress in Clinical and Biological Research

Carcinogenesis

J.Pharm.Pharmacol

Fitoterapia

Phytother. Res.

Phytother. Res.

J. Ethnopharmacology

J. Pharm. Pharmacol.

Biochem. Pharmacol.

Biochem. Pharmacol.

Biochem. Pharmacol.

Planta Medica

Fitoterapia

Minerva Medica

Arzneim. Forsch.

Experientia

Pharmacognosy and Pharmacobiotechnology

Toxicology

Flavonoids and Bioflavonoids

Jpn. J. Vet. Soc.

J. Gen. Microbiol.

Biochem.Soc.Trans.

Planta Medica

Life Sci.

Biochem. Biophys. Res. Comm.

Calcif. Tissue Int.

Clin. Exp. Metastasis

Cancer Lett.

Eur. J. Pharmacol.

Minireview
Flavonoids: Old and new aspects of a class of natural therapeutic drugs