Elsevier

Tetrahedron

Volume 45, Issue 13, 1989, Pages 4177-4190
Tetrahedron

Application of the vicinal oxyamination reaction with asymmetric induction to the hemisynthesis of taxol and analogues

Dedicated to the memory of Professor Edgar Lederer.
https://doi.org/10.1016/S0040-4020(01)81313-2Get rights and content

Abstract

Taxol, 10-deacetyl taxol and their related side chain analogues can be obtained via a “Sharpless” oxyamination reaction on 13-cinnamoyl baccatin III. Asymmetric induction has been studied using different bridgehead amines as chiral ligands. This procedure constitutes an alternative route to taxol derivatives for biological studies.

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