Cell
Volume 78, Issue 5, 9 September 1994, Pages 773-785
ArticleThe ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB
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2022, European Journal of Medicinal ChemistryCitation Excerpt :Moreover, the statistical results more intuitively showed that the relative expression of VEGFR-2 significantly increased after adding the two ligand inhibitors (Fig. 10B). Furthermore, the degradation of VEGFR-2 protein was also obviously blocked after treatment with the proteasome inhibitor MG-132 [41] or the NAE inhibitor MLN4924 [42] for the corresponding time (Fig. 10C). Although only adding MG-132 degraded part of VEGFR-2, its degradation efficiency was not as good as that of protein degradation group, and the addition of P7 after inhibiting proteasome function did not result in degradation.
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