CorrespondenceFatal liver complications with flutamide
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Cited by (26)
Inhibition of biliary network reconstruction by benzbromarone delays recovery from pre-existing liver injury
2019, ToxicologyCitation Excerpt :These studies mostly focused on the initial onset of hepatotoxicity, whereas the deterioration mechanism that eventually leads to a fatal outcome is not well-understood. It is notable from clinical observations that DILI patients with poor prognosis display sustained high serum bilirubin levels, and can even die after administration of a suspicious drug is discontinued (Arai et al., 2002; Osculati and Castiglioni, 2006; Watkins and Whitcomb, 1998). Indeed, serum bilirubin levels have long been considered one of the prognostic indices of fatal liver injury based on empirical observations (Zimmerman, 1978).
The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p
2017, Biochemical PharmacologyCitation Excerpt :However, the interaction between lansoprazole and flutamide should be considered since a severe adverse reaction could occur. Flutamide is an androgen receptor antagonist that is primarily prescribed to treat advanced prostate cancer in men and to treat acne, hirsutism, and alopecia in women with polycystic ovary syndrome [53]. Despite the efficacy of its anti-androgen effects, flutamide-dependent hepatotoxicity represents a significant health concern, since the incidence of the adverse reaction could be as high as 9% in patients [54], and the severity of flutamide-dependent hepatotoxicity could lead to liver transplantation or death [55].
The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4
2016, Biochemical PharmacologyCitation Excerpt :However, only the expression of Abcc4 mRNA was induced by 2-fold after short-term FLU treatment for 3 days, and no significant change in Fxr, Shp, and Abcb11 mRNA levels was noted (Fig. 8G-I), thus suggesting that the FXR inhibition in liver is a secondary event triggered by FLU. Clinical use of FLU has been associated with hepatotoxicity, as indicated by temporary elevations in transaminase markers in up to 62% of patients, and rare incidences of severe liver dysfunction [27,28]. The common pattern of FLU-caused hepatotoxicity was described as cholestatic hepatitis.
Application of lipid peroxidation products as biomarkers for flutamide-induced oxidative stress in vitro
2015, Toxicology LettersCitation Excerpt :Flutamide is a non-steroidal androgen receptor antagonist used for treatment of prostate cancer. Due to occurrence of severe incidences of hepatic injury, it has been labeled with a black box warning by the FDA (Kraus et al., 2001; Osculati and Castiglioni, 2006). Although many studies have been performed to elucidate the cause of flutamide toxicity, the exact mechanism remains elusive.
Reply of the authors
2012, Fertility and SterilityIdiosyncratic Drug-Induced Liver Injury: Mechanisms and Susceptibility Factors
2010, Comprehensive Toxicology, Second Edition