Simulation models to predict oral drug absorption from in vitro data
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2020, LWTCitation Excerpt :Physical parameters include the following: solubility, dissolution rate, molecular weight, partition coefficient, chemical degradation, and delivery system. Therein, the solubility and dissolution rate are interrelated and affect the ability of the compound to be solubilized rapidly enough for absorption to occur (Grass, 1997). Numerous studies have demonstrated that the poor water solubility of the active components of a natural product is a principal detrimental factor in its application and bioactivities.
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2016, Journal of Drug Delivery Science and TechnologyCitation Excerpt :The facilitated diffusion and the active transport are more complex absorption mechanisms in which a carrier is involved. Absorption can be estimated using a number of experimental methods including common in vivo based models [2]; bioavailability can be determined from separate oral and intra-venous animal dosing studies [3], and fraction absorbed data can be obtained from oral dosing to animals with cannulated hepatic veins [4]. Alternatively, the absorption process can be considered instead in terms of the two key components: permeability and solubility [5], which can be measured using cell systems [6] or other devices [7].