Metabolism of carcinogenic N-nitroso-N-methylaniline by purified cytochromes P450 2B1 and P450 2B2
References (34)
- et al.
Toxicity and oncogenicity of nitrosomethylaniline and nitrosomethylcyclohexylamine
Toxicol. Appl. Pharmacol.
(1970) - et al.
An investigation of the metabolism of N-nitroso-N-methylaniline by phenobarbital- and pyrazole-induced Sprague-Dawley rat liver and esophagus derived S-9
Chem.-Biol. Interact.
(1987) - et al.
Metabolic denitrosation of N-nitroso-N-methylaniline: detection of amine-metabolites
Chem.-Biol. Interact.
(1991) - et al.
The first identification of the benzenediazonium ion formation from non-aminoazo dye, 1-phenylazo-2-hydroxynaphthalene (Sudan I) by microsomes of rat livers
Cancer Lett.
(1988) - et al.
The carbon monooxide-binding pigment of liver microsomes, I: evidence for its hemoprotein nature
J. Biol. Chem.
(1964) - et al.
Identification of the high and low potential flavins of liver microsomal NADPH-cytochrome P-450 reductase
J. Biol. Chem.
(1978) A rapid sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Anal. Biochem.
(1976)- et al.
Further characterization of cytochrome P450 involved in phytoalexin synthesis in soybean: cytochrome P450 cinnamate 4-hydroxylase and 3,9-dihydroxypterocarpan 6a-hydroxylase
Arch. Biochem. Biophys.
(1992) - et al.
The enigma of the organ-specificity of carcinogenic nitrosamines
Trends Pharmacol. Sci.
(1987) - et al.
Peroxidase oxidizes N-nitrosomethy-laniline to ultimate carcinogen(s) binding to DNA and transfer RNA in vitro
Cancer Lett.
(1992)
Organotropic carcinogenicity of 65 different N-nitroso compounds in BD rats
Z. Krebsforsch.
(1967)
N-Nitroso carcinogens
The effect of substituents in the aromatic ring on carcinogenicity of N-nitrosomethylaniline in F344 rats
Carcinogenesis
(1983)
Evidence for an unstable DNA adduct from N-nitroso-N-methylaniline
Chem. Res. Toxicol.
(1990)
N-nitroso-N-methylaniline: possible mode of DNA modification
Carcinogene Wirkung von 13 Aryldialkyltriazenes an BD-Ratten
Z. Krebsforsch.
(1974)
Carcinogenicity tests of acetoxymethylphenylnitrosamine and benzenediazonium tetrafluoroborate in Syrian hamster
Cancer Lett.
(1982)
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