Role of the aromatic hydrocarbon receptor in the suppression of cytochrome P-450 2C11 by polycyclic aromatic hydrocarbons
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Cited by (24)
Aromatic hydrocarbon receptors in mitochondrial biogenesis and function
2021, MitochondrionCitation Excerpt :Some studies evaluated the role of AhR under oxidative stress. AhR has an important role in dealing with oxidative stress by upregulating several antioxidants (Safa et al., 1997). It is shown that oxidative stress induced by hydrogen peroxide (H2O2) results in translocation of AhR into the nucleus of human melanocytes in ligand-dependent or –independent manner (Bansal et al., 2014).
Gonadotropin and estrogen responses in freshwater turtle (Chrysemys picta) from Cape Cod, Massachusetts
2006, General and Comparative EndocrinologyAromatic hydrocarbon receptor expression and function in liver of hypophysectomized male rats
2002, Toxicology and Applied PharmacologyTranscriptional suppression of cytochrome P450 2C11 gene expression by 3-methylcholanthrene
2000, Biochemical PharmacologyCitation Excerpt :The cloning and sequencing of approximately 2.3 kb of the 5′-flanking region of the CYP2C11 gene [43, 44], together with our demonstration that MC decreases the rate of transcription of the CYP2C11 gene, set the stage for detailed molecular investigations of the mechanisms by which PAHs alter the transcription of this gene. Since most of the biological effects of TCDD and PAHs are mediated by the AHR [1], and we have some structure–activity evidence to suggest that the AHR is involved in CYP2C11 down-regulation by PAHs [22], we are exploring the 5′-flanking region of the CYP2C11 gene for transcriptional regulatory sites that may be modulated by the AHR or other trans-acting factors. In addition, the main physiological signal that regulates the male-specific hepatic CYP2C11 expression is the pulsatile pattern of growth hormone secretion [19], and this positive hormonal regulation occurs at the transcriptional level [23, 24].
PCB 118 induces ultrastructural alterations in the rat liver
2000, Toxicology