Roles of the JAK-STAT system in signal transduction via cytokine receptors

doi:10.1016/S0959-437X(96)80088-8

Current Opinion in Genetics & Development

Volume 6, Issue 5, October 1996, Pages 587-596

https://doi.org/10.1016/S0959-437X(96)80088-8 Get rights and content

Abstract

JAK-STAT signaling pathways are known to play an essential role in the specific activation of interferon-inducible genes. Many cytokines interacting with the cytokine receptor superfamily also appear to activate these pathways. Recent evidence indicates that JAKs play an essential role(s) in cytokine receptor signaling, including both specific pathways linked to STATs and general pathways regulating cell growth and functions.

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