Meeting paperSMFM paperThe frequency of microbial invasion of the amniotic cavity and histologic chorioamnionitis in women at term with intact membranes in the presence or absence of labor
Section snippets
Study design
A retrospective analysis was conducted on pregnant women at term with intact membranes who delivered singleton neonates (gestational age 37 weeks or longer) at Seoul National University Hospital and who had AF retrieved at the time of cesarean delivery. This criterion (inclusion of patients whose AF was obtained at the time of cesarean delivery) was used to preserve a meaningful temporal relationship between the results of AF studies and the histological findings of the placenta and umbilical
Results
A total of 884 singleton pregnant women were enrolled and divided into 3 groups according to the presence or absence of labor and the progress of labor: group 1, women not in labor (n = 775); group 2, women in early labor (cervical dilatation less than 4 cm) (n = 86); group 3, women in active labor (cervical dilatation 4 cm or greater) (n = 23).
The clinical indications for cesarean deliveries included previous cesarean section (n = 632), malpresentation (n = 118), placenta previa (n = 30),
Comment
The principal findings of this study were: (1) MIAC and histologic chorioamnionitis is present in 1% and 6% of patients in term pregnancy with intact membranes, respectively; (2) the presence of labor at term is associated with an increased risk of MIAC and a higher median AF WBC count; (3) patients who had entered the active phase of labor at term with intact membranes had a higher rate of MIAC and histologic chorioamnionitis than those with a cervical dilatation of less than 4 cm; and (4)
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Cited by (0)
This study was supported by grant R01-2006-000-10607-0 from the Korea Science and Engineering Foundation, funded by the Korean government (Ministry of Science and Technology).
Cite this article as: Seong HS, Lee SE, Kang JH, et al. The frequency of microbial invasion of the amniotic cavity and histologic chorioamnionitis in women at term with intact membranes in the presence or absence of labor. Am J Obstet Gynecol 2008;199:375.e1-375.e5.