ReviewThe transport of anti-HIV drugs across blood–CNS interfaces: Summary of current knowledge and recommendations for further research
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Abbreviations
BBB
blood–brain barrier
P-gp
P-glycoprotein
MRP
multi-drug resistance associated protein
HAART
highly active antiretroviral therapy
PIs
protease inhibitors
NRTIs
nucleoside reverse transcriptase inhibitors
NNRTIs
non-nucleoside reverse transcriptase inhibitors
NtRTIs
nucleotide reverse transcriptase inhibitors
HAD
HIV-associated dementia
HIVE
HIV encephalitis
MND
mild neurocognitive disorder
MDR-1
multi-drug resistance gene 1
BCRP
breast cancer resistance protein
OAT
organic anion transporter
OATP
organic anion-transporting polypeptide
CSF
cerebrospinal fluid
CNS
central nervous system
AIDS
acquired immunodeficiency syndrome
HAD
HIV-associated dementia
ABC
ATP binding cassette
SLC
solute carrier superfamily
ddI
2′,3′-dideoxyinosine
ddC
2′3′-dideoxycytidine
3TC
(−)-2′-deoxy-3′-thiacytidine
AZT
zidovudine
ENT
equilibrative nucleoside transporter
CNT
concentrative nucleoside transporter
ET-1
endothelin-1
LPS
lipopolysaccharide
Keywords
Blood–brain barrier
Choroid plexus
HIV
HAART
Transporters
P-Glycoprotein
Antiretroviral drugs
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Copyright © 2009 Elsevier B.V.