Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Volume 1832, Issue 1, January 2013, Pages 121-127
GLUT12 functions as a basal and insulin-independent glucose transporter in the heart
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Highlights
► Use of a biotinylated photolabeled assay in perfused myocardium and cardiac myocytes ► Insulin increased translocation of GLUT-4, but not -12, in the healthy myocardium ► Diabetes induced alteration in insulin-stimulated GLUT-4, but not -12, translocation. ► Active cell surface GLUT12 was increased in the diabetic myocardium.
Abbreviations
GLUT
glucose transporters
Dx
diabetes
Con
control
L
labeled
UL
unlabeled
CASQ
calsequestrin
Keywords
Diabetes
GLUT translocation
Exofacial bis-mannose photolabeling
Myocytes
Perfused myocardium
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