6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2
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Biological importance of structurally diversified chromenes
2016, European Journal of Medicinal ChemistryCitation Excerpt :Among the cyanostilbene subset of chromenes, 142 with 6-CHC(CN)Ph and R1 = H, presented the highest activating potential (7.4%). Starcevic et al. tested 6- and 7-phenyl coumarins 143 (Fig. 25) as selective nonsteroidal inhibitors of 17β –HSD1 (17β-hydroxysteroid dehydrogenase type 1) [157]. A series of mimetics of steroidal structures with improved inhibition of 17β –HSD1 was evaluated.
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2012, Bioorganic and Medicinal ChemistryCitation Excerpt :Many reports on the selectivity of inhibitors to AKR1B1 over AKR1A1 have been published,16–19 however, no report has been made on the inhibitory selectivity to AKR1B1 over AKR1B10. In recent years, many kinds of AKR1B1 inhibitors have been found from natural sources, such as flavones, flavonoids, coumarins and so on.20 In our search for AKR1B1 inhibitors, we found that a hot water extract of Evodia rutaecarpa exhibited significant inhibitory activity and reported that rhetsinine, which is a minor alkaloidal component of E. rutaecarpa, significantly suppressed sorbitol accumulation in human erythrocytes by 79.3% at 100 μM.21
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2020, Future Medicinal Chemistry