Chemistry & Biology
Volume 12, Issue 6, June 2005, Pages 621-637
Journal home page for Chemistry & Biology

Review
Features of Selective Kinase Inhibitors

https://doi.org/10.1016/j.chembiol.2005.04.011Get rights and content
Under an Elsevier user license
open archive

Summary

Small-molecule inhibitors of protein and lipid kinases have emerged as indispensable tools for studying signal transduction. Despite the widespread use of these reagents, there is little consensus about the biochemical criteria that define their potency and selectivity in cells. We discuss some of the features that determine the cellular activity of kinase inhibitors and propose a framework for interpreting inhibitor selectivity.

Cited by (0)