Cell Metabolism
Volume 18, Issue 3, 3 September 2013, Pages 307-309
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FGF21 Mimetic Shows Therapeutic Promise

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FGF21 is a protein with multiple metabolic actions, currently a bright star beckoning on the metabolic disease therapeutic horizon. Gaich et al. (2013) present the first clinical efficacy trial for an FGF21 mimetic, finding robust lipid-lowering effects, some reduction in body weight, but surprisingly modest effects on glucose homeostasis.

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