Physiologically-based pharmacokinetic models for children: Starting to reach maturation?
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Keywords
Pediatrics
Children
Ontogeny
PBPK
Physiologically-based pharmacokinetic modeling
Model-informed drug dosing
Abbreviations
CYP
cytochrome P450
DDI
drug-drug interaction
GFR
glomerular filtration rate
GST
glutathione s-transferase
kp
tissue-plasma partitioning coefficient
mAB
monoclonal antibody
OAT
organic anion transporter
OCT
organic cation transporter
PBPK
Physiologically-based pharmacokinetic
UGT
UDP-glucuronosyltransferase.
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© 2020 The Author(s). Published by Elsevier Inc.