Research ArticlesPhysiologically based pharmacokinetics of digoxin in mdr1a knockout mice
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2016, Journal of Pharmaceutical SciencesCitation Excerpt :It is considered that organic anion transporter (oat) 1 and oat3 mainly contribute to the uptake of anionic drugs by epithelial cells from blood.15 The BBM also expresses many transporters, including multidrug resistance protein (mdr) 1a/P-glycoprotein (P-gp), breast cancer resistance protein (bcrp), and multidrug resistance-associated protein (mrp) 4, which have been shown to contribute to drug transport by means of studies in gene-knockout mice.2,4,16 However, the differences in average transport activities among different transporters are poorly understood, in contrast to BLM transporters.
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Faculty of Pharmaceutical Sciences, Kanazawa University.
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Present address: Hospital Pharmacy, School of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641.
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CREST, Japan Science and Technology Corporation.