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Mechanisms of drug transfer across the human placenta.

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Abstract

In this review we summarized literature data on the mechanisms of human placental drug transport studied in the isolated perfused placental cotyledon, placental membrane vesicles or trophoblastic cell cultures. Overall human placental drug transport rarely exceeds the transfer of flow‐dependent and membrane‐limited marker compounds. Interestingly, relatively often placental drug transfer appeared to be much smaller, indicating impaired trans-placental transport, depending on the physico-chemical characteristics of the drug or placental factors such as tissue binding or metabolism. Although in perfusion studies overall human placental drug transport occurs by simple diffusion, at the membrane level several drug transport systems have been found, mainly for drugs structurally related to endogenous compounds.

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Authors and Affiliations

  1. Departments of Pharmacology and Toxicology, Faculty of Medical Sciences, University of Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands

    Eric M. van der Aa, Jenny H.J. Copius Peereboom-Stegeman, Jan Noordhoek, Frank W.J. Gribnau & Frans G.M. Russel

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  1. Eric M. van der Aa
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  2. Jenny H.J. Copius Peereboom-Stegeman
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van der Aa, E.M., Copius Peereboom-Stegeman, J.H., Noordhoek, J. et al. Mechanisms of drug transfer across the human placenta.. Pharm World Sci 20, 139–148 (1998). https://doi.org/10.1023/A:1008656928861

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