Abstract
EPOXIDE rings are known to be enzymatically hydrated by numerous organisms1–3 to give predominantly the corresponding trans-dihydroxy compounds and the epoxide hydrases involved can moderate various types of bioactivity. Thus, they are involved in the deactivation of certain labile aromatic epoxides which may be responsible for carcino-genesis2 and in the detoxication of insecticides such as 1-naphthyl-N-methylcarbamate (carbaryl) or the cyclodiene dieldrin.
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BROOKS, G. Insect Epoxide Hydrase Inhibition by Juvenile Hormone Analogues and Metabolic Inhibitors. Nature 245, 382–384 (1973). https://doi.org/10.1038/245382a0
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DOI: https://doi.org/10.1038/245382a0
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