Abstract
A new study calls for further investigation into the potential benefits and risks of COX-2 specific inhibitors (pages 698–701).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Gilroy, D.W. et al. Inducible cyclooxygenase may have anti-inflammatory properties. Nature Med. 5, 698–701 (1999).
Vane, J.R. Inhibition of prostaglandin synthesis as a mechanism of action for the aspirin-like drugs. Nature New Biol. 231, 232– 235 (1971).
Fu, J., Masferrer, J., Seibert, K. Raz, A. & Needleman, P. The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes. J. Biol. Chem. 265, 16737–16742 (1990).
Kujubu, D.A., Fletcher, B.S., Varnum, B.C., Lim, R.W. & Herschman, H.R. TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells encodes a novel prostaglandin synthase/cycloxoygenase homologue. J. Biol. Chem. 266 , 12866–12872 (1991).
Xie, W., Chipman, J.G., Robertson, D.L, Erikson, R.L. & Simmons, D.L. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc. Natl. Acad. Sci. USA 88, 2692– 2696 (1991).
Seibert, K. et al. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc. Natl. Acad. Sci. USA 91, 12013–12017 (1994).
Black, C. et al. 2-3-Diarylcyclopentenones as orally active, highly selective cyclooxygenase-2 inhibitors. J. Med. Chem. 42, 1274–1281 (1999).
Zhang, Y., Shaffer, A., Portanova, J., Seibert, K. & Isakson, P. Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hypoeralgesia and prostaglandin E2 production. J. Pharmacol. Exp. Ther. 282, 1069– 1075 (1997).
Smith, C. et al. Pharmacologic analysis of cyclooxygeanse-1 in inflammation. Proc. Natl. Acad. Sci. USA 95, 13313– 13318 (1998).
Anderson, G., Hauser, S., McGarity, K., Bremer, M., Isakson, P. & Gregory, S. Selective inhibition of cyclooxygenase (COX-2) reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis. J. Clin. Invest. 97, 2672–2679 (1996).
Mizuno, H. et al. Induction of cyclooxygenase-2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice. Gastroenterology 112, 387–397 (1997).
Tsuji, M. et al. Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 93, 705–716 (1998).
Reddy, B.S., Rao, C.V. & Seibert, K. Evaluation of cyclooxygenase-2 inhibitor for potential chemopreventive properties in colon carcinogenesis. Cancer Res. 6, 4506–4569 ( 1996).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Seibert, K., Lefkowith, J., Tripp, C. et al. COX-2 Inhibitors – Is there cause for concern?. Nat Med 5, 621–622 (1999). https://doi.org/10.1038/9465
Issue Date:
DOI: https://doi.org/10.1038/9465
This article is cited by
-
Augmentation of allergic inflammation in prostanoid IP receptor deficient mice
British Journal of Pharmacology (2002)
