Research ArticleHuman monocyte-derived cells with individual hepatocyte characteristics: a novel tool for personalized in vitro studies
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Keywords
cytochrome P450
hepatocyte model
in vitro testing
personalized medicine
toxicity
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Supplementary Information accompanies the paper on the Laboratory Investigation website
Differences in hepatic metabolism have a major impact on individual drug response. Peripheral human monocytes (MH) are presented as a novel tool to investigate long term hepatic toxicity, metabolism and drug interactions. Since MH-derived cells retain gender-specific and donor-specific cytochrome P450 superfamily activities and toxicity profiles, they mimic hepatocyte metabolism.
Supplementary information: The online version of this article (doi:10.1038/labinvest.2012.64) contains supplementary material, which is available to authorized users.
© 2012 United States & Canadian Academy of Pathology.