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Aryl Hydrocarbon Hydroxylase Induction by Polycyclic Hydrocarbons: Simple Autosomal Dominant Trait in the Mouse

Nature New Biology volume 236, pages 107–110 (1972)Cite this article

Abstract

MANY mixed function1 oxygenases are membrane-bound multicomponent enzyme systems which require NADPH and molecular oxygen for the oxidative metabolism of polycyclic hydrocarbons, drugs and insecticides, as well as numerous lipophilic endogenous substrates2–4. Any day to day fluctuations in these enzyme activities may therefore influence the intensity and duration of drug action and also the rate of metabolism of chemical carcinogens, insecticides and many normal body substrates.

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Authors and Affiliations

  1. Section on Developmental Pharmacology, Laboratory of Biomedical Sciences, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, 20014

    D. W. NEBERT, F. M. GOUJON & J. E. GIELEN

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  1. D. W. NEBERT
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  2. F. M. GOUJON
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  3. J. E. GIELEN
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NEBERT, D., GOUJON, F. & GIELEN, J. Aryl Hydrocarbon Hydroxylase Induction by Polycyclic Hydrocarbons: Simple Autosomal Dominant Trait in the Mouse. Nature New Biology 236, 107–110 (1972). https://doi.org/10.1038/newbio236107a0

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