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Melanoma metastasis: new concepts and evolving paradigms

Oncogene volume 33, pages 2413–2422 (2014)Cite this article

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Abstract

Melanoma progression is typically depicted as a linear and stepwise process in which metastasis occurs relatively late in disease progression. Significant evidence suggests that in a subset of melanomas, progression is much more complex and less linear in nature. Epidemiologic and experimental observations in melanoma metastasis are reviewed here and are incorporated into a comprehensive model for melanoma metastasis, which takes into account the varied natural history of melanoma formation and progression.

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Authors and Affiliations

  1. Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA

    W E Damsky, N Theodosakis & M Bosenberg

  2. Department of Pathology, University of Vermont College of Medicine, Burlington, VT, USA

    W E Damsky

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  1. W E Damsky
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  2. N Theodosakis
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Damsky, W., Theodosakis, N. & Bosenberg, M. Melanoma metastasis: new concepts and evolving paradigms. Oncogene 33, 2413–2422 (2014). https://doi.org/10.1038/onc.2013.194

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