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Planta Med 1996; 62(5): 453-457
DOI: 10.1055/s-2006-957938
Paper

© Georg Thieme Verlag Stuttgart · New York

Main Ginseng Saponin Metabolites Formed by Intestinal Bacteria

Hideo Hasegawa1 , Jong-Hwan Sung2 , Satoshi Matsumiya1 , Masamori Uchiyama1
  • 1Itto Institute of Life Science Research, Happy World Inc., 3-13-8, Shiraitodai, Fuchu-shi, Tokyo, 183, Japan
  • 2Central Research Institute, IL HWA Co., Ltd., 437, Suteak-dong, Guri-shi, Kyonggi-do, Korea
Further Information

Publication History

1995

1996

Publication Date:
04 January 2007 (online)

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Abstract

Ginseng saponin metabolites produced by human intestinal bacteria and the urinary and blood compounds after oral administration of Ginseng extract and its saponins in human and specific pathogen-free rats were examined in order to elucidate their metabolites absorbed from the intestines. The main metabolites of ginsenosides Rb1, Rb2, Rc, Re, and Rg1 after anaerobic incubation with fecal flora were identified as 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol (I) 20-O-[α-L-arabinopyranosyl (1→6)-β-D-glucopyranosyl]-20(S)-protopanaxadiol (II), 20-O-[α-L-arabinofuranosyl(1→6)-β-D-glucopyranosyl]-20(S)-protopanaxadiol (III), and 20(S)-protopanaxatriol (IV), though the metabolic rate and mode were affected by fermentation media. Furthermore, metabolites I-IV and 20(S)-protopanaxadiol (XII) were detected in blood (0.3-5.1 µg/ml) and in urine (2.2-96 µg/ day) after the oral administration of Ginseng extract (150 mg/kg/day) to human and of total saponin (1 g/kg/day) to rats.

Key words

Panax ginseng - Araliaceae - Ginseng saponin - intestinal bacteria - metabolite - human - rat - absorption

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