Degradation of Ginseng Saponins under Mild Acidic Conditions

B. H. Han; M. H. Park; Y. N. Han; L. K. Woo; U. Sankawa; S. Yahara; O. Tanaka

doi:10.1055/s-2007-971425

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Planta Med 1982; 44(3): 146-149
DOI: 10.1055/s-2007-971425

Research Articles

Degradation of Ginseng Saponins under Mild Acidic Conditions

B. H. Han¹ , M. H. Park¹ , Y. N. Han¹ , L. K. Woo¹ , U. Sankawa² , S. Yahara³ , O. Tanaka³

¹Natural Product Research Institute, Seoul National University, Seoul, Korea
²Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
³Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Hiroshima, Japan

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Publication History

Publication Date:
29 March 2007 (online)

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Abstract

Ginseng saponins, ginsenosides Rg₁, Re and Rb₁, decomposed under mild acidic conditions to yield prosapogenins. The structures of the prosapogenins were investigated by ¹³C-NMR spectroscopy and Rg₁-prosapogenin II was shown to be a mixture of ginsenoside Rh₁, and its C-20 epimer, produced by hydrolysis followed by epimerization at C-20. Rg₁-prosapogenin III, the other prosapogenin derived from ginsenoside Rg₁; was a C-25,26 hydrated derivative of Rg₁-prosapogenin II. Re-prosapogenin II was identified as a mixture of ginsenoside Rg₂ and its C-20 epimer, and Re-prosapogenine III as a C-25,26 hydrated derivative of Re-prosapogenin II.

Key Word Index

Panax ginseng - Araliaceae - Saponin - Ginsenoside - Prosapogenin

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