ReviewThe Organic Anion Transporter (OATP) Family
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2017, Toxicology LettersCitation Excerpt :Thus, the different types of Oatps in the kidneys of mice and rats might be responsible for the differences observed in nephrotoxicity. To the best of our knowledge, Oatp1a1, Oatp2a1, Oatp1a3, Oatp1a5, Oatp2b1, Oatp3a1, Oatp4a1 and Oatp1a6 occur in the kidneys of rats and Oatp1a1, Oatp2a1, Oatp1a4, Oatp1a5, Oatp3a1, Oatp1a6 and Oatp2b1 occur in the kidneys of mice (Cheng et al., 2005; Cheng and Klaassen 2009; Kim 2003; Kusuhara and Sugiyama 2002; Mikkaichi et al., 2004; Tsujimoto et al., 2013; Zaïr et al., 2008), which may indicate that the Oatps specific to the kidneys of rats might play a vital role in the observed differences in nephrotoxicity. These assumptions require further exploration.
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