NoteEffect of Tea Beverages on Aldehyde Oxidase Activity
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Cited by (23)
Non-cytochrome P450 enzymes involved in the oxidative metabolism of xenobiotics: Focus on the regulation of gene expression and enzyme activity
2022, Pharmacology and TherapeuticsCitation Excerpt :Raloxifene was the most potent drug that showed a half-maximal inhibitory concentration (IC50) of 2.9 nM (Obach, Huynh, Allen, & Beedham, 2004). Compounds from natural products, such as catechin derivatives, flavonoids, and stilbenoids also show a comparable inhibitory effect on AOX at low micromolar concentrations (Barr, Jones, Oberlies, & Paine, 2015; Hamzeh-Mivehroud, Rahmani, Rashidi, Hosseinpour Feizi, & Dastmalchi, 2013; Tayama et al., 2011). Some of these inhibitors with micromolar potency also have a potency comparable to CYP450s at the same concentration (Nirogi et al., 2014).
Inhibitory effects of drugs on the metabolic activity of mouse and human aldehyde oxidases and influence on drug–drug interactions
2018, Biochemical PharmacologyCitation Excerpt :Furthermore, hydralazine has been shown to be an inhibitor of AOX activity in rabbit, guinea pig, baboon, and human liver [17–19]. In addition to drugs, diet-derived constituents were also reported to inhibit AOX activity (e.g., epicatechin gallate and epigallocatechin gallate) [20,21]. In this context, an interesting compound is represented by norharmane, which exhibits an isoform-specific inhibitory effect on AOX3 in mouse liver [13].
Xanthine Oxidoreductase and Aldehyde Oxidases
2018, Comprehensive Toxicology: Third EditionEffect of Bakumondo-to on cytochrome P450 activities in rat liver microsomes
2016, Journal of King Saud University - ScienceCitation Excerpt :St John’s wort (Hypericum perforatum), an herbal antidepressant, is also well-known as a potent inducer of cytochrome P450 (CYP) 3A (Roby et al., 2000; Wang et al., 2001). In addition, analogs of catechin are inhibitors of CYPs, xanthine oxidase, and aldehyde oxidase (Tayama et al., 2011). Shoseiryuto, another traditional herbal medication, demonstrated CYP3A inhibitory activity in rat liver microsomes (Makino et al., 2006).
Significance of aldehyde oxidase during drug development: Effects on drug metabolism, pharmacokinetics, toxicity, and efficacy
2015, Drug Metabolism and PharmacokineticsCitation Excerpt :Furthermore, 6-deoxypenciclovir and zoniporide show substrate inhibition at high concentrations, allowing the prediction of PK in humans [85]. Constituents of green tea, oolong tea, and blended tea have been shown to inhibit aldehyde oxidase activity [86], with concentration-dependent decreases in NMN metabolism. Contents of tea include caffeine (103.1 mg/L), epigallocatechin gallate (196.0 mg/L), epigallocatechin (78.1 mg/L), gallocatechin gallate (70.5 mg/L), epicatechin (28.5 mg/L), catechin (25.6 mg/L), and epicatechin gallate (19.6 mg/L), and among these catechin, epigallocatechin, epicatechin, and epicatechin gallate are potential inhibitors of aldehyde oxidase [86].
Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients
2012, Nutrition ResearchCitation Excerpt :The polyphenolic structure allows electron delocalization, conferring high reactivity to quench free radicals [37]. Tea catechins eliminate reactive oxygen and nitric radicals, and also act as chelators of metal ions active in the redox system [38,39]. The antioxidant action of GTE may also explain the hypotensive and cardioprotective action of GTE.