Regular ArticleProfiling and Trend Analysis of Food Effects on Oral Drug Absorption Considering Micelle Interaction and Solubilization by Bile Micelles
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2024, European Journal of Pharmaceutical SciencesFed intestinal solubility limits and distributions applied to the Developability classification system
2023, European Journal of Pharmaceutics and BiopharmaceuticsMachine learning methods for prediction of food effects on bioavailability: A comparison of support vector machines and artificial neural networks
2022, European Journal of Pharmaceutical SciencesCitation Excerpt :This finding correlates well to the Fleisher et al. summary of FE prediction based on BCS class where Class 3 drugs, of poor permeability and good solubility, are likely to exhibit negative FE (Fleisher et al., 1999). Such negative FE were previously associated with highly hydrophilic drugs displaying a narrow window of absorption (Kawai et al., 2011, Gu et al., 2007). Dose was also a significant parameter in classify drugs by FE on AUC.
Leveraging bile solubilization of poorly water-soluble drugs by rational polymer selection
2021, Journal of Controlled ReleaseCitation Excerpt :Throughout the manuscript we are using the terms “MIM interacting drugs” or “MIM non-interacting drugs” to indicate the interaction of drugs with TC/L MIM. The flux across these artifical membranes has been previously correlated to bioavailability [49–51]. The outcome of our experiments led to a preliminary decision tree by which drug substances are firstly categorized in those for which interaction with bile colloids is critical or not.
Control of oral absorption of nutritional supplement using lipid-based formulations (LBFs): Application to the poorly water-soluble ingredient
2020, Journal of Drug Delivery Science and TechnologyCitation Excerpt :However, this is not the case for this study, since FeSSIF simply contains NaTC and lecithin as 5-times higher concentration than FaSSIF [24–26]. The possible reasons of reduced BA of sesamin when administered with FeSSIF have not been clarified yet, however, the direct interaction of sesamin with bile acid (NaTC) or lipid (lecithin) in FeSSIF is most conceivable [35]. In addition, entrapment in the mixed micelles of bile acids/lecithin is also the possible factor because it might reduce the free fraction of sesamin in the GI tract.