Regular ArticleUtility of Cryopreserved Hepatocytes Suspended in Serum to Predict Hepatic Clearance in Dogs and Monkeys
References (60)
- et al.
Species difference of esterase expression and hydrolase activity in plasma
J. Pharm. Sci.
(2012) Inter-species differences in drug properties
Chem. Biol. Interact.
(2001)- et al.
Stereoselective pharmacokinetics of bisoprolol after intravenous and oral administration in beagle dogs
J. Pharm. Sci.
(1997) - et al.
Effect of oral ketoconazole on first-pass effect of nifedipine after oral administration in dogs
J. Pharm. Sci.
(2002) - et al.
Comparative pharmacokinetics of antipyrine (phenazone) in the baboon, cynomolgus monkey and rhesus monkey
Toxicology
(1981) - et al.
Urinary excretion of an uracilic metabolite from caffeine by rat, monkey and man
Toxicol. Lett.
(1981) - et al.
Secondary bioenergetic hypoxia. Inhibition of sulfation and glucuronidation reactions in isolated hepatocytes at low O2 concentration
J. Biol. Chem.
(1982) - et al.
Depletion of ATP but not of GSH affects viability of rat hepatocytes
Eur. J. Pharmacol.
(1992) Determination of the hepatocellularity number for human, dog, rabbit, rat and mouse livers from protein concentration measurements
Toxicol. In Vitro
(2006)- et al.
Stereoselective metabolism of bisoprolol enantiomers in dogs and humans
Life Sci.
(1998)
Prediction of species differences (rats, dogs, humans) in the in vivo metabolic clearance of YM796 by the liver from in vitro data
J. Pharmacol. Exp. Ther.
(1997)
Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans
Drug Metab. Dispos.
(2001)
In vivo pharmacokinetics of felodipine predicted from in vitro studies in rat, dog and man
Acta Pharmacol. Toxicol. (Copenh.)
(1986)
Prediction of hepatic metabolic clearance based on interspecies allometric scaling techniques and in vitro-in vivo correlations
Clin. Pharmacokinet.
(1999)
Bosentan, a new endothelin receptor antagonist: prediction of the systemic plasma clearance in man from combined in vivo and in vitro data
Xenobiotica
(1995)
Utility of hepatocytes in predicting drug metabolism: comparison of hepatic intrinsic clearance in rats and humans in vivo and in vitro
Drug Metab. Dispos.
(2003)
Esterase activities in the blood, liver and intestine of several preclinical species and humans
Drug Metab. Lett.
(2009)
N-glucuronidation of drugs and other xenobiotics by human and animal UDP-glucuronosyltransferases
Xenobiotica
(2011)
Mammalian aldehyde oxidases: genetics, evolution and biochemistry
Cell. Mol. Life Sci.
(2008)
In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase
Drug Metab. Dispos.
(2010)
Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance
Biochem. Pharmacol.
(1994)
Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes, and the intact liver: studies with induced livers involving diazepam
Drug Metab. Dispos.
(1997)
A convenient in vitro screening method for predicting in vivo drug metabolic clearance using isolated hepatocytes suspended in serum
Drug Metab. Dispos.
(2000)
Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes
Pharm. Res.
(2004)
Prediction of metabolic clearance using cryopreserved human hepatocytes: kinetic characteristics for five benzodiazepines
Drug Metab. Dispos.
(2005)
A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes
Drug Metab. Dispos.
(2005)
Practical use of the regression offset approach for the prediction of in vivo intrinsic clearance from hepatocytes
Xenobiotica
(2012)
Evaluation of the human prediction of clearance from hepatocyte and microsome intrinsic clearance for 52 drug compounds
Xenobiotica
(2010)
Prediction of human metabolic clearance from in vitro systems: retrospective analysis and prospective view
Pharm. Res.
(2010)
Prediction of hepatic clearance and availability by cryopreserved human hepatocytes: an application of serum incubation method
Drug Metab. Dispos.
(2002)
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