Effects of Propofol Analogs on Glucuronidation of Propofol, an Anesthetic Drug, by Human Liver Microsomes

Title: Effects of Propofol Analogs on Glucuronidation of Propofol, an Anesthetic Drug, by Human Liver Microsomes

Volume: 1 Issue: 1

Author(s): Makiko Shimizu, Yoshiaki Matsumoto and Hiroshi Yamazaki

Affiliation:

Keywords: Propofol, UGT1A9, inhibitor, glucuronidation, human, 2,5-diisopropylphenol

Abstract: prevent rapid forming O-glucuronide of propofol (2,6-diisopropylphenol), an intravenous anesthetic, effects To of propofol analogs were investigated. Propofol was predominately glucuronidated by human UGT1A9 and intestinal or liver microsomes. 2,5-Diisopropylphenol inhibited the propofol glucuronidation. A possibility of developing orally administrable agents or of reducing propofol dose by coadministration is suggested.

Cite this article as:

Shimizu Makiko, Matsumoto Yoshiaki and Yamazaki Hiroshi, Effects of Propofol Analogs on Glucuronidation of Propofol, an Anesthetic Drug, by Human Liver Microsomes, Drug Metabolism Letters 2007; 1 (1) . https://dx.doi.org/10.2174/187231207779814355