Abstract
Historically, there has been intense interest in P450 metabolic oxidation, peroxidation, and reduction of xenobiotics. More recently, there has been a growing appreciation for the role of P450s in the oxidation of lipophilic endobiotics, such as bile acids, fat-soluble vitamins, and eicosanoids. This review details the emerging CYP2J subfamily of P450s and their role as catalysts of arachidonic acid metabolism.
MeSH terms
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Animals
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Arachidonic Acid / metabolism*
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Biotransformation
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Chromosome Mapping
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Cytochrome P-450 CYP2J2
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Cytochrome P-450 Enzyme System / classification
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Cytochrome P-450 Enzyme System / genetics*
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Cytochrome P-450 Enzyme System / metabolism*
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Cytochrome P-450 Enzyme System / physiology
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Humans
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Oxygenases / genetics
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Oxygenases / metabolism*
Substances
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Arachidonic Acid
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Cytochrome P-450 Enzyme System
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Oxygenases
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Cytochrome P-450 CYP2J2