Low-dose subcutaneous ketamine infusion and morphine tolerance

Pain. 1999 Oct;83(1):101-3. doi: 10.1016/s0304-3959(99)00096-2.

Abstract

The NMDA receptor has been reported to be involved in opioid tolerance. Adjuvant subcutaneous infusion treatment with (very) low-dose ketamine, a NMDA receptor antagonist, improves analgesia and at the same time appears to reduce morphine tolerance. Three cases are presented.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Analgesics / administration & dosage
  • Analgesics / therapeutic use*
  • Drug Administration Schedule
  • Female
  • Humans
  • Ketamine / administration & dosage
  • Ketamine / therapeutic use*
  • Male
  • Morphine / administration & dosage
  • Morphine / therapeutic use
  • Neoplasms / physiopathology
  • Pain, Intractable / drug therapy*
  • Pain, Intractable / etiology

Substances

  • Analgesics
  • Ketamine
  • Morphine