Abstract
The NMDA receptor has been reported to be involved in opioid tolerance. Adjuvant subcutaneous infusion treatment with (very) low-dose ketamine, a NMDA receptor antagonist, improves analgesia and at the same time appears to reduce morphine tolerance. Three cases are presented.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Analgesics / administration & dosage
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Analgesics / therapeutic use*
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Drug Administration Schedule
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Female
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Humans
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Ketamine / administration & dosage
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Ketamine / therapeutic use*
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Male
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Morphine / administration & dosage
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Morphine / therapeutic use
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Neoplasms / physiopathology
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Pain, Intractable / drug therapy*
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Pain, Intractable / etiology
Substances
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Analgesics
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Ketamine
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Morphine