Biomimetic Fe(II)-mediated degradation of arteflene (Ro-42-1611). The first EPR spin-trapping evidence for the previously postulated secondary carbon-centered cyclohexyl radical

J Org Chem. 2000 Mar 10;65(5):1578-82. doi: 10.1021/jo991585m.

Authors

P M O'Neill¹, L P Bishop, N L Searle, J L Maggs, R C Storr, S A Ward, B K Park, F Mabbs

Affiliation

¹ Departments of Chemistry and of Pharmacology and Therapeutics, University of Liverpool, P.O. Box 147, Liverpool L69 3BX, U.K.

PMID: 10814129
DOI: 10.1021/jo991585m

No abstract available

MeSH terms

Alkylation
Animals
Antimalarials / chemistry
Antimalarials / metabolism*
Antimalarials / pharmacology
Artemisinins*
Benzenesulfonates
Bridged Bicyclo Compounds, Heterocyclic / chemistry*
Bridged Bicyclo Compounds, Heterocyclic / metabolism*
Bridged Bicyclo Compounds, Heterocyclic / pharmacology
Cyclohexanes / chemistry
Cyclohexanes / metabolism*
Drugs, Chinese Herbal / chemistry
Drugs, Chinese Herbal / metabolism
Drugs, Chinese Herbal / pharmacology
Electron Spin Resonance Spectroscopy
Ferrous Compounds / metabolism*
Free Radicals / chemistry
Free Radicals / metabolism
Heme / chemistry
Heme / metabolism
Magnetic Resonance Spectroscopy
Nitroso Compounds
Oxidation-Reduction
Plasmodium falciparum / drug effects
Spin Labels
Styrenes / chemistry*
Styrenes / metabolism*
Styrenes / pharmacology

Substances

Antimalarials
Artemisinins
Benzenesulfonates
Bridged Bicyclo Compounds, Heterocyclic
Cyclohexanes
Drugs, Chinese Herbal
Ferrous Compounds
Free Radicals
Nitroso Compounds
Spin Labels
Styrenes
Heme
arteflene
3,5-dibromo-4-nitrosobenzenesulfonate