Abstract
From the aerial parts of Decatropis bicolor, heraclenin (1), seselin (2), psoralen (3), imperatorin (4), skimmianine (5), and heraclenol (6), were isolated. This is the first time that coumarin-like compounds are isolated from Decatropis genus. The anti-inflammatory properties of compounds 1-6 were examined against the ear edema in mice produced by TPA. The results suggest that the anti-inflammatory activity of each compound depends of its individual substitution on the aromatic ring rather than the coumarin skeleton itself.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Coumarins / isolation & purification
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Coumarins / pharmacology*
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Coumarins / therapeutic use
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Disease Models, Animal
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Edema / chemically induced
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Edema / drug therapy*
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Mice
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Plants, Medicinal / chemistry*
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Tetradecanoylphorbol Acetate / toxicity
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Coumarins
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Tetradecanoylphorbol Acetate