Abstract
The development of the apparent kinetic parameters K- m and V-max was studied in perinatal Wistar rats for three functionally diverse, hepatic enzymes (p-nitroanisole O-demethylase, carboxylesterase and bromosulphophthalein-glutathione conjugating enzyme), the period studied being from 3 days prepatum to 35 days postpartum. The kinetic parameters underwent marked quantitative changes during development, which appeared to be independent of sex for the first 5 weeks postpartum.
MeSH terms
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Aging
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Animals
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Animals, Newborn
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Anisoles
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Body Weight
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DNA / metabolism
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Esterases / metabolism*
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Female
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Fetus
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Glutathione
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Kinetics
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Ligases / metabolism*
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Liver / anatomy & histology
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Liver / growth & development
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Liver / metabolism*
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Male
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Organ Size
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Oxidoreductases / metabolism*
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Pregnancy
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Proteins / metabolism
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RNA / metabolism
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Rats
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Sex Factors
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Sulfobromophthalein
Substances
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Anisoles
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Proteins
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Sulfobromophthalein
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RNA
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DNA
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Oxidoreductases
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Esterases
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Ligases
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Glutathione