Abstract
The importance of Jak-Stat pathway signaling in regulating cytokine-dependent gene expression and cellular development/survival is well established. Nevertheless, advances continue to be made in defining Jak-Stat pathway effects on different cellular processes and in different organisms. This review focuses on recent advances in the field and highlights some of the most active areas of Jak-Stat pathway research.
MeSH terms
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Animals
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Carrier Proteins / metabolism
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Cytokines / metabolism*
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DNA-Binding Proteins / chemistry
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DNA-Binding Proteins / metabolism*
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Gene Expression Regulation
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Humans
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Intracellular Signaling Peptides and Proteins*
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Janus Kinase 1
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Methylation
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Protein Inhibitors of Activated STAT
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Protein-Tyrosine Kinases / metabolism*
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Proteins / metabolism
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Receptors, Cytokine / metabolism
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Repressor Proteins*
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STAT1 Transcription Factor
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Signal Transduction*
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Suppressor of Cytokine Signaling 1 Protein
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Suppressor of Cytokine Signaling Proteins
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Trans-Activators / chemistry
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Trans-Activators / metabolism*
Substances
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Carrier Proteins
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Cytokines
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DNA-Binding Proteins
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Intracellular Signaling Peptides and Proteins
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Protein Inhibitors of Activated STAT
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Proteins
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Receptors, Cytokine
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Repressor Proteins
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SOCS1 protein, human
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STAT1 Transcription Factor
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STAT1 protein, human
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Suppressor of Cytokine Signaling 1 Protein
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Suppressor of Cytokine Signaling Proteins
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Trans-Activators
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Protein-Tyrosine Kinases
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JAK1 protein, human
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Janus Kinase 1