Abstract
Digoxin is often coadministered with carvedilol in children with severe ventricular failure. In eight children (age 2 weeks to 8 years), the oral clearance of digoxin decreased by half with carvedilol, and two of them had digoxin toxicity. Carvedilol increases serum concentrations of digoxin in children, and its dose may need to be reduced to avoid toxicity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Carbazoles / adverse effects
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Carbazoles / pharmacokinetics
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Carbazoles / therapeutic use*
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Cardiomyopathy, Dilated / drug therapy*
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Cardiotonic Agents / adverse effects
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Cardiotonic Agents / pharmacokinetics
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Cardiotonic Agents / therapeutic use*
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Carvedilol
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Child
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Child, Preschool
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Digoxin / adverse effects
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Digoxin / pharmacokinetics
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Digoxin / therapeutic use*
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Drug Interactions
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Female
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Humans
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Hypoplastic Left Heart Syndrome / drug therapy*
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Infant
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Infant, Newborn
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Male
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Propanolamines / adverse effects
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Propanolamines / pharmacokinetics
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Propanolamines / therapeutic use*
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Vasodilator Agents / adverse effects
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Vasodilator Agents / pharmacokinetics
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Vasodilator Agents / therapeutic use*
Substances
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Carbazoles
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Cardiotonic Agents
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Propanolamines
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Vasodilator Agents
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Carvedilol
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Digoxin