Abstract
A series of 11,12-EET analogues were synthesized and compared using a human endothelial cell based TNF-alpha-induced VCAM-1 expression assay. The resulting data were used to map a putative recognition/binding domain for 11,12-EET.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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8,11,14-Eicosatrienoic Acid / analogs & derivatives*
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8,11,14-Eicosatrienoic Acid / chemical synthesis
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8,11,14-Eicosatrienoic Acid / chemistry*
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8,11,14-Eicosatrienoic Acid / pharmacology*
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Animals
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Binding Sites
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Endothelium, Vascular / drug effects
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Endothelium, Vascular / physiology
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Humans
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Molecular Structure
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Structure-Activity Relationship
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Tumor Necrosis Factor-alpha / antagonists & inhibitors
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Tumor Necrosis Factor-alpha / pharmacology*
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Vascular Cell Adhesion Molecule-1 / chemistry
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Vascular Cell Adhesion Molecule-1 / drug effects
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Vascular Cell Adhesion Molecule-1 / genetics*
Substances
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Tumor Necrosis Factor-alpha
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Vascular Cell Adhesion Molecule-1
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11,12-epoxy-5,8,14-eicosatrienoic acid
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8,11,14-Eicosatrienoic Acid