Heat increases 3,4-methylenedioxymethamphetamine self-administration and social effects in rats

Jennifer L Cornish; Zeeshan Shahnawaz; Murray R Thompson; Suzanna Wong; Kirsten C Morley; Glenn E Hunt; Iain S McGregor

doi:10.1016/j.ejphar.2003.09.060

Heat increases 3,4-methylenedioxymethamphetamine self-administration and social effects in rats

Eur J Pharmacol. 2003 Dec 15;482(1-3):339-41. doi: 10.1016/j.ejphar.2003.09.060.

Authors

Jennifer L Cornish¹, Zeeshan Shahnawaz, Murray R Thompson, Suzanna Wong, Kirsten C Morley, Glenn E Hunt, Iain S McGregor

Affiliation

¹ School of Psychology, University of Sydney, A19 NSW 2006, Australia.

PMID: 14660042
DOI: 10.1016/j.ejphar.2003.09.060

Abstract

3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") is a drug frequently used under hot conditions in nightclubs. In rats tested in the social interaction paradigm, greater prosocial effects of MDMA (5.0 mg/kg) were seen at a hot temperature (30 degrees C) relative to normal laboratory temperature (21 degrees C). In the intravenous drug self-administration paradigm, hot temperature (30 degrees C) increased the number of MDMA infusions (0.1, 0.3 or 1.0 mg/kg/infusion) self-administered by rats. Hot temperatures thus appear to affect both the social and reinforcing effects of MDMA.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Hot Temperature*
Interpersonal Relations*
Male
Motor Activity / drug effects*
Motor Activity / physiology
N-Methyl-3,4-methylenedioxyamphetamine / administration & dosage*
Rats
Rats, Wistar
Self Administration

Substances

N-Methyl-3,4-methylenedioxyamphetamine