Expression of the liver X receptor alpha and beta in embryonic and adult mice

Anat Rec A Discov Mol Cell Evol Biol. 2004 Apr;277(2):312-6. doi: 10.1002/ar.a.20015.

Abstract

We characterized the expression pattern of the nuclear receptors liver X receptor (LXR) alpha and beta during mouse embryonic development and in adulthood by in situ hybridization experiments. LXRalpha and LXRbeta are detected in the liver starting at 11.5 days postcoitum. Later, LXRalpha expression remains high in organs involved in lipid homeostasis, such as liver, intestine, and brown adipose tissue, whereas LXRbeta is more ubiquitously expressed and enriched in tissues of neuronal and endocrine origin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue, Brown / embryology
  • Adipose Tissue, Brown / metabolism
  • Animals
  • Blotting, Northern
  • DNA-Binding Proteins / metabolism*
  • Gene Expression Profiling*
  • Gene Expression Regulation, Developmental
  • Intestinal Mucosa / metabolism
  • Intestines / embryology
  • Liver / embryology
  • Liver / metabolism*
  • Liver X Receptors
  • Mice
  • Orphan Nuclear Receptors
  • RNA, Messenger / analysis
  • Receptors, Cytoplasmic and Nuclear / genetics
  • Receptors, Cytoplasmic and Nuclear / metabolism*

Substances

  • DNA-Binding Proteins
  • Liver X Receptors
  • Nr1h3 protein, mouse
  • Orphan Nuclear Receptors
  • RNA, Messenger
  • Receptors, Cytoplasmic and Nuclear