CYP3A and P-glycoprotein activity induction with St. John's Wort in healthy volunteers from 6 ethnic populations

J Clin Pharmacol. 2005 Mar;45(3):352-6. doi: 10.1177/0091270004273320.
No abstract available

Publication types

  • Clinical Trial
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / biosynthesis*
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics
  • Adult
  • Asian People
  • Black or African American
  • Cytochrome P-450 CYP3A / biosynthesis*
  • Female
  • Genotype
  • Herb-Drug Interactions / ethnology*
  • Hispanic or Latino
  • Humans
  • Hypericum*
  • Male
  • Midazolam / blood
  • Midazolam / pharmacokinetics*
  • Middle Aged
  • Phenotype
  • Plant Preparations / pharmacology*
  • Terfenadine / analogs & derivatives*
  • Terfenadine / blood
  • Terfenadine / pharmacokinetics
  • White People

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Plant Preparations
  • Terfenadine
  • fexofenadine
  • Cytochrome P-450 CYP3A
  • Midazolam