p53 Activation by small molecules: application in oncology

J Med Chem. 2005 Jul 14;48(14):4491-9. doi: 10.1021/jm058174k.
No abstract available

Publication types

  • Review

MeSH terms

  • Animals
  • Anticarcinogenic Agents / chemistry
  • Anticarcinogenic Agents / pharmacology
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Carrier Proteins / antagonists & inhibitors
  • Carrier Proteins / biosynthesis
  • Humans
  • Imidazoles / chemistry
  • Imidazoles / pharmacology
  • Models, Molecular
  • Neoplasms / drug therapy
  • Neoplasms / metabolism*
  • Neoplasms / prevention & control
  • Piperazines / chemistry
  • Piperazines / pharmacology
  • Protein Binding
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • Anticarcinogenic Agents
  • Antineoplastic Agents
  • Carrier Proteins
  • Imidazoles
  • Mtbp protein, mouse
  • Piperazines
  • Tumor Suppressor Protein p53
  • nutlin 1
  • nutlin 2
  • nutlin 3