Abstract
As the indications for zidovudine (ZDV) treatment in human immunodeficiency virus-infected individuals expand, we anticipate an increased use of this drug during pregnancy. We report pharmacokinetics data from a patient studied both in the third trimester and intrapartum. ZDV peak-plasma levels and serum half-lives were comparable to nonpregnant adults. High concentrations of ZDV and its glucuronide metabolite were found in umbilical cord blood and in amniotic fluid.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Amniotic Fluid / chemistry
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Female
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Fetal Blood / chemistry
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HIV Infections / drug therapy
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HIV Infections / metabolism*
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Humans
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Infant, Newborn
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Milk, Human / chemistry
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Pregnancy
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Pregnancy Complications, Infectious / drug therapy
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Pregnancy Complications, Infectious / metabolism*
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Zidovudine / analysis
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Zidovudine / pharmacokinetics*
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Zidovudine / therapeutic use