Replacement of natural cofactors by selected hydrogen peroxide donors or organic peroxides results in improved activity for CYP3A4 and CYP2D6

Chembiochem. 2006 Jun;7(6):916-9. doi: 10.1002/cbic.200600006.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biotechnology
  • Catalysis
  • Chromatography, High Pressure Liquid
  • Cytochrome P-450 CYP2D6 / chemistry*
  • Cytochrome P-450 CYP2D6 / metabolism
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 Enzyme System / chemistry*
  • Cytochrome P-450 Enzyme System / metabolism
  • Enzyme Activation
  • Humans
  • Hydrogen Peroxide / chemistry*
  • Hydrogen Peroxide / metabolism
  • Hydroxylation
  • Kinetics
  • NADP / chemistry*
  • NADP / metabolism
  • Peroxides / chemistry*
  • Peroxides / metabolism
  • Up-Regulation

Substances

  • Peroxides
  • NADP
  • Cytochrome P-450 Enzyme System
  • Hydrogen Peroxide
  • Cytochrome P-450 CYP2D6
  • Cytochrome P-450 CYP3A
  • CYP3A4 protein, human